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Research Clinical Trials Clinical Trials      
Scientific Research
Clinical Trials Report or Abstract

Clinical Trials and Research undertaken into the Buteyko Method and related issues.

Beta2-Agonist Tolerance and Exercise-induced Bronchospasm
Source: Am. J. Respir. Crit. Care Med., Volume 165, Number 8, April 2002, 1068-1070 Robert J. Hancox, Padmaja Subbarao, Dennis Kamada, Richard M. Watson, Fredrick E. Hargreave, and Mark D. Inman Asthma Research Group, Firestone Institute for Respiratory Health, McMaster University/St Joseph's Hospital, Hamilton, Ontario, Canada

The effect of regular inhaled beta-agonist on the treatment of exercise-induced bronchoconstriction was studied. Eight subjects with exercise-induced bronchoconstriction took 1 week each of salbutamol 200 µg qid or placebo in a random-order, double-blind, crossover study. They then withheld this treatment for 8 hours before performing a dry-air, sub-maximal exercise challenge at a work-rate previously shown to induce a 15% fall in forced expiratory volume in 1 second (FEV1). Five minutes after exercise, they inhaled salbutamol 100, 100, and 200 µg at 5-minute intervals. The mean pre-exercise FEV1 was similar on both study days. However, pretreatment for 1 week with salbutamol led to a significantly greater fall in FEV1 after exercise. The FEV1 remained lower than during the placebo arm despite the administration of salbutamol after exercise. This difference persisted 25 minutes after exercise. It is concluded that regular -agonist treatment leads to increased exercise-induced bronchoconstriction and a suboptimal bronchodilator response to beta-agonist. The data suggest that previous regular beta-agonist treatment may lead to a failure to respond to emergency bronchodilator treatment during an acute asthma attack and support current opinion that regular short-acting beta-agonist therapy should not be used to treat asthma.

More Clinical Trials

Breathing exercises for asthma: a randomised controlled trial
Thorax 2009; 64:55-61 [Abstract] [Full Text]

A Randomised Controlled Trial of the Buteyko Technique for Asthma Management
Respiratory Medicine May 2008 (Vol. 102, Issue 5, Pages 726-732) [Abstract] [Full Text]

Canadian Buteyko Trial 2008
 [Abstract]

Beta-agonists trigger T cell accumulation
J Allergy Clin Immunol 2006 [Abstract]

Asthma exacerbations in children immediately following stressful life events: a Cox's heirarchical regression
S Sandberg, S Jarvenpaa, A Penttinen, J Y Paton, and D C McCann Thorax 2004;59 1046-1051 [Abstract] [Full Text]

Ventilation Test In Patients With Bronchial Asthma
Buteiko KP, Odintsova MP, Nasonkina NS. Vrach Delo. 1968 Apr; 4:33-6. PMID: 5664602 [PubMed - indexed for MEDLINE] [Abstract]

Obstructive Sleep Apnoea and breathing retraining
Mary Birch, RN,BA,MBioE, Grad Dip Soc, BIBHClinical Update 74, Australian Nursing Journal, August 2004 [Text]

Buteyko Breathing Technique for asthma: an effective intervention
Patrick McHugh, Fergus Aitcheson, Bruce Duncan, Frank Houghton Journal of the New Zealand Medical Association, 12-December-2003, Vol 116 No 1187 [Abstract] [Full Text]

Health Education: Does the Buteyko Institute Method make a difference?
Jill McGowan, Education and training consultant in Asthma Management.Thorax Vol 58, suppl III, page 28, December 2003. [Abstract] [Full Text]

Beta2-Agonist Tolerance and Exercise-induced Bronchospasm
Am. J. Respir. Crit. Care Med., Volume 165, Number 8, April 2002, 1068-1070 Robert J. Hancox, Padmaja Subbarao, Dennis Kamada, Richard M. Watson, Fredrick E. Hargreave, and Mark D. Inman Asthma Research Group, Firestone Institute for Respiratory Health, McMaster University/St Joseph's Hospital, Hamilton, Ontario, Canada  [Abstract]

End-tidal carbon dioxide measurements as a prognostic indicator of outcome in cardiac arrest.
Ahrens T, Schallom L, Bettorf K, Ellner S, Hurt G, O'Mara V, Ludwig J, George W, Marino T, Shannon W. Barnes-Jewish Hospital, St. Louis, MO, USA. Am J Crit Care 2001 Nov;10(6):391-8 [Abstract]

Repeated Hyperventilation Causes Peripheral Airways Inflammation, Hyperreactivity, and Impaired Bronchodilation in Dogs
MICHAEL S. DAVIS and ARTHUR N. FREED Am. J. Respir. Crit. Care Med., Volume 164, Number 5, September 2001, 785-789 [Abstract]

Cardiovascular side effects of inhaled salbutamol in hypoxic asthmatic patients
Thorax; London; Jul 2001; J Burggraaf; R G J Westendorp; J C C M In't Veen; R C Schoemaker; et al;  [Abstract]

Study explains success of Buteyko
Megan Howe - Australian Doctor, p 20, 11 May 2001 [Text]

Prevalence of dysfunctional breathing in patients treated for asthma in primary care: a cross sectional survey
M Thomas, RK McKinley, E Freeman, C Foy British Medical Journal 2001;322:1098-1100 (5 May) [Abstract]

Hyperventilation and asymptomatic chronic asthma
Thorax; London; Dec 2000; C A Osborne; B J O'Connor; A Lewis; Van Kanabar; W N Gardner; [Abstract]

Buteyko breathing techniques in asthma: a blinded randomised trial
Simon D Bowler, Amanda Green and Charles A Mitchell Medical Journal of Australia 1998; 169:575-578 [Abstract] [Full Text]

Effects of inhaled CO2 and added dead space on idiopathic central sleep apnea
Xje A. Rankin F. Rutherford R. Bradly TD. Journal of Applied Physiology, 82(3):918-26, 1997 Mar. [Abstract]

Changing patterns in asthma morbidity and mortality.
Sears MR J-Investig-Allergol-Clin-Immunol 1995 Mar-Apr; 5(2): 66-72.  [Abstract]

Beneficial effect of inhaled CO2 in a patient with non-obstructive sleep apnoea.
J Neurol 1993 Nov;241(11:45-8 (ISSN: C340-5354) Villiger PM; Hess CW; Reinhart WH Medizinische Klinik der Universitat, Inselspital, Bern, Switzerland [Abstract]

Rediscovering the importance of nasal breathing in sleep or, shut your mouth and save your sleep
Lavie P J Layngol Otol 1987 June;101(6):558-63 [Abstract]

Breathing Patterns
Chest, 1983, 84:202-205Tobin et al (Summary) [Abstract]


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