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Research Clinical Trials Clinical Trials      
Scientific Research
Clinical Trials Report or Abstract

Clinical Trials and Research undertaken into the Buteyko Method and related issues.

Beta-agonists trigger T cell accumulation
Source: J Allergy Clin Immunol 2006

Nov 28, 2006 - Bronchodilators appear to increase inflammation, potentially worsening asthma, heart failure, and lupus, study findings suggest.

In laboratory tests on peripheral blood lymphocytes (PBL), Raymond Penn (Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA) and colleagues showed that b-agonists, such as those used to treat asthma, increase the accumulation of type 2 T cells.

This is a pertinent finding, the scientists believe, as an over-reactive type 2 T cell response is thought to contribute to inflammatory diseases, such as asthma and lupus.

The researchers report in an advance online publication by the Journal of Allergy and Clinical Immunology, that when they added b-agonists to PBL cultured with interleukin (IL)-2, they saw an increased IL-2-induced accumulation of human type 2 T cells.

They suggest that, as b-agonists belong to a class of chemicals that includes adrenalin, the immune responses of patients with elevated adrenalin levels, such as those with emotional distress and heart failure, may also be altered, thus worsening disease.

“Inhaled b-agonists are very effective in opening up airways and allowing asthmatics to breathe, but their ability to address the underlying inflammation that causes most asthma has been debated for years,” said Penn.

In fact, many clinical trials have reported worsening symptoms in asthma patients on continuous b-agonist therapy. Current US Food and Drug Administration recommendations suggest asthma patients receiving long-acting b-agonists be supplemented with inhaled corticosteroids.

“From an asthma management standpoint, these studies further emphasize the need to include anti-inflammatory corticosteroids when treating moderate to severe asthma,” the researchers conclude.

More Clinical Trials

Breathing exercises for asthma: a randomised controlled trial
Thorax 2009; 64:55-61 [Abstract] [Full Text]

A Randomised Controlled Trial of the Buteyko Technique for Asthma Management
Respiratory Medicine May 2008 (Vol. 102, Issue 5, Pages 726-732) [Abstract] [Full Text]

Canadian Buteyko Trial 2008
 [Abstract]

Beta-agonists trigger T cell accumulation
J Allergy Clin Immunol 2006 [Abstract]

Asthma exacerbations in children immediately following stressful life events: a Cox's heirarchical regression
S Sandberg, S Jarvenpaa, A Penttinen, J Y Paton, and D C McCann Thorax 2004;59 1046-1051 [Abstract] [Full Text]

Ventilation Test In Patients With Bronchial Asthma
Buteiko KP, Odintsova MP, Nasonkina NS. Vrach Delo. 1968 Apr; 4:33-6. PMID: 5664602 [PubMed - indexed for MEDLINE] [Abstract]

Obstructive Sleep Apnoea and breathing retraining
Mary Birch, RN,BA,MBioE, Grad Dip Soc, BIBHClinical Update 74, Australian Nursing Journal, August 2004 [Text]

Buteyko Breathing Technique for asthma: an effective intervention
Patrick McHugh, Fergus Aitcheson, Bruce Duncan, Frank Houghton Journal of the New Zealand Medical Association, 12-December-2003, Vol 116 No 1187 [Abstract] [Full Text]

Health Education: Does the Buteyko Institute Method make a difference?
Jill McGowan, Education and training consultant in Asthma Management.Thorax Vol 58, suppl III, page 28, December 2003. [Abstract] [Full Text]

Beta2-Agonist Tolerance and Exercise-induced Bronchospasm
Am. J. Respir. Crit. Care Med., Volume 165, Number 8, April 2002, 1068-1070 Robert J. Hancox, Padmaja Subbarao, Dennis Kamada, Richard M. Watson, Fredrick E. Hargreave, and Mark D. Inman Asthma Research Group, Firestone Institute for Respiratory Health, McMaster University/St Joseph's Hospital, Hamilton, Ontario, Canada  [Abstract]

End-tidal carbon dioxide measurements as a prognostic indicator of outcome in cardiac arrest.
Ahrens T, Schallom L, Bettorf K, Ellner S, Hurt G, O'Mara V, Ludwig J, George W, Marino T, Shannon W. Barnes-Jewish Hospital, St. Louis, MO, USA. Am J Crit Care 2001 Nov;10(6):391-8 [Abstract]

Repeated Hyperventilation Causes Peripheral Airways Inflammation, Hyperreactivity, and Impaired Bronchodilation in Dogs
MICHAEL S. DAVIS and ARTHUR N. FREED Am. J. Respir. Crit. Care Med., Volume 164, Number 5, September 2001, 785-789 [Abstract]

Cardiovascular side effects of inhaled salbutamol in hypoxic asthmatic patients
Thorax; London; Jul 2001; J Burggraaf; R G J Westendorp; J C C M In't Veen; R C Schoemaker; et al;  [Abstract]

Study explains success of Buteyko
Megan Howe - Australian Doctor, p 20, 11 May 2001 [Text]

Prevalence of dysfunctional breathing in patients treated for asthma in primary care: a cross sectional survey
M Thomas, RK McKinley, E Freeman, C Foy British Medical Journal 2001;322:1098-1100 (5 May) [Abstract]

Hyperventilation and asymptomatic chronic asthma
Thorax; London; Dec 2000; C A Osborne; B J O'Connor; A Lewis; Van Kanabar; W N Gardner; [Abstract]

Buteyko breathing techniques in asthma: a blinded randomised trial
Simon D Bowler, Amanda Green and Charles A Mitchell Medical Journal of Australia 1998; 169:575-578 [Abstract] [Full Text]

Effects of inhaled CO2 and added dead space on idiopathic central sleep apnea
Xje A. Rankin F. Rutherford R. Bradly TD. Journal of Applied Physiology, 82(3):918-26, 1997 Mar. [Abstract]

Changing patterns in asthma morbidity and mortality.
Sears MR J-Investig-Allergol-Clin-Immunol 1995 Mar-Apr; 5(2): 66-72.  [Abstract]

Beneficial effect of inhaled CO2 in a patient with non-obstructive sleep apnoea.
J Neurol 1993 Nov;241(11:45-8 (ISSN: C340-5354) Villiger PM; Hess CW; Reinhart WH Medizinische Klinik der Universitat, Inselspital, Bern, Switzerland [Abstract]

Rediscovering the importance of nasal breathing in sleep or, shut your mouth and save your sleep
Lavie P J Layngol Otol 1987 June;101(6):558-63 [Abstract]

Breathing Patterns
Chest, 1983, 84:202-205Tobin et al (Summary) [Abstract]


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