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Research Clinical Trials Clinical Trials      
Scientific Research
Clinical Trials Report or Abstract

Clinical Trials and Research undertaken into the Buteyko Method and related issues.

Cardiovascular side effects of inhaled salbutamol in hypoxic asthmatic patients
Source: Thorax; London; Jul 2001; J Burggraaf; R G J Westendorp; J C C M In't Veen; R C Schoemaker; et al;

Abstract
Background-Beta-2 adrenoceptor agonists have been associated with sudden death in asthma patients but the cause and underlying mechanism are unclear. Animal experiments indicate that the combination of hypoxia and beta^sub 2^ agonists may result in detrimental cardiovascular effects. A study was undertaken to investigate the effect of hypoxia on the systemic vascular effects of salbutamol in patients with asthma who are hypoxic by assessing forearm blood flow (FBF) as a measure of peripheral vasodilatation.
Methods-Eight men with mild asthma underwent the following treatments: normoxia + placebo (NP), normoxia + salbutamol (NS), hypoxia + placebo (HP), and hypoxia + salbutamol (HS). The period of mask breathing started at t=0 minutes, lasted for 60 minutes, and at 30 minutes 800 (mu)g salbutamol was inhaled. The experiment was completed 30 minutes after the inhalation (t=60 minutes). For the hypoxia treatment the SpO^sub 2^= level was 82%. Differences between treatments were sought using factorial ANOVA on percentage change from the pretreatment value.
Results-There were no significant differences in blood pressure and potassium levels between the treatments. After 60 minutes the increase in FBF was 13% (95% CI -12 to 39) more for HP treatment than for NP, 21% (95% Cl -5 to 46) more for NS than for NP, and 32% (95% CI 7 to 58) more for HS than for HP (p=0.016). The inhalation of salbutamol during hypoxia resulted in a significant increase in FBF of 45% (95% CI 20 to 71) compared with NP (p=0.001).
Conclusion-Patients with asthma who are hypoxic and inhale beta^sub 2^ agonists have serious systemic vascular side effects which may be an additional explanation for the association between asthma treatment and sudden death.
(Thorax 2001;56:567-569)
Keywords: asthma; hypoxia; beta^sub 2^ agonists

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